5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>[OH-].[Na+]>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1参加物
3
実験手順
A mixture of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (1.50 g), prepared in a similar manner to that described in Example 11, and aqueous sodium hydroxide solution (1M; 40 ml) was stirred for 2 hours. The mixture was filtered, the solid washed with water (2×10 ml) and then dried in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 234°-235° (1.19 g).
後処理
- customprepared in a similar manner to that
- filtrationThe mixture was filtered
- washthe solid washed with water (2×10 ml)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-f673797ccbd14ce09739de13439c9bff
- 出典データセット
- uspto-grants-1991_04
- 特許番号
- US05011931
反応ノート
読み込み中…