Acetic Acid → Npc182939

HRID 1085934

反応式

HRID 1085934 の反応式
[CH3:1][C@H:2]1[C@@H:12]2[CH2:13][CH2:14][C@@:15]3([CH3:19])[O:17][O:18][C@:11]42[C@H:5]([C@@H:6]([CH3:20])[C:7]([O:9][C@@H:10]4[O:16]3)=[O:8])[CH2:4][CH2:3]1.[BH4-].[Na+].C(O)(=O)C>CO>[CH3:1][C@H:2]1[C@@H:12]2[CH2:13][CH2:14][C:15]3([CH3:19])[O:17][O:18][C@:11]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:8])[O:9][C@@H:10]4[O:16]3)[CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 68827ArtemisininHCID 4311764Sodium borohydride

生成物 1

HCID 456410Npc182939

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4 g (0.014 m) of qinghaosu (I) in 200 ml of methanol, was added 4 g of sodium borohydride in small portions, keeping the reaction mixture at 0°-5°. After stirring for 60 min, the mixture was neutralized with glacial acetic acid, concentrated and diluted with water. The white precipitate formed was collected and dried. Recrystallization of the solid from acetone-hexane afforded white needles mp: 153°-58° C., 3.2 g (80).

後処理

  1. customat 0°-5°
  2. concentrationconcentrated
  3. additiondiluted with water
  4. customThe white precipitate formed
  5. customwas collected
  6. customdried
  7. customRecrystallization of the solid from acetone-hexane afforded white needles mp: 153°-58° C., 3.2 g (80)

出典と根拠

ORDレコード
ord-2dde5313947f46a090dca57632cbefff
出典データセット
uspto-grants-1991_04
特許番号
US05011951

関連ノート

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