4-Acetylpyridine → 4-Trifluoromethylbenzoic acid [1-(4pyridinyl)ethylidene]hydrazide

HRID 1085957

反応式

HRID 1085957 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=O)[CH3:2].[F:10][C:11]([F:23])([F:22])[C:12]1[CH:21]=[CH:20][C:15]([C:16]([NH:18][NH2:19])=[O:17])=[CH:14][CH:13]=1>C(O)C>[N:7]1[CH:8]=[CH:9][C:4]([C:1](=[N:19][NH:18][C:16](=[O:17])[C:15]2[CH:14]=[CH:13][C:12]([C:11]([F:10])([F:23])[F:22])=[CH:21][CH:20]=2)[CH3:2])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 142824-AcetylpyridineHCID 5206624-(Trifluoromethyl)benzohydrazide

生成物 1

HCID 538678224-Trifluoromethylbenzoic acid [1-(4pyridinyl)ethylidene]hydrazide収率 84%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2.97 gm (0.0245 mole) of 4-acetylpyridine, 5.0 gm (0.0245 mole) of 4-trifluoromethylbenzhydrazide and 100 ml of absolute ethanol is refluxed for 6 hr. The hot solution is filtered. The filtrate is diluted with water to the cloud point, cooled to room temperature and chilled. The crystals which separate are collected, washed with water and dried to yield 6.29 gm (84%) of the title compound having a melting point of 198.4° C.

後処理

  1. temperatureis refluxed for 6 hr
  2. filtrationThe hot solution is filtered
  3. additionThe filtrate is diluted with water to the cloud point
  4. temperaturechilled
  5. customThe crystals which separate
  6. customare collected
  7. washwashed with water
  8. customdried

出典と根拠

ORDレコード
ord-fa282594d35946fd91d63e933799e28c
出典データセット
uspto-grants-1991_04
特許番号
US05011932

関連ノート

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