4-Acetylpyridine → HCID 3285123、化合物

HRID 1085959ノート

反応式

HRID 1085959 の反応式
[Cl:1][C:2]1[CH:13]=[C:12]([Cl:14])[C:11]([Cl:15])=[CH:10][C:3]=1[O:4][CH2:5][C:6]([NH:8][NH2:9])=[O:7].[C:16]([C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)(=O)[CH3:17].O1CCOCC1>C(O)(=O)C>[N:22]1[CH:23]=[CH:24][C:19]([C:16](=[N:9][NH:8][C:6](=[O:7])[CH2:5][O:4][C:3]2[CH:10]=[C:11]([Cl:15])[C:12]([Cl:14])=[CH:13][C:2]=2[Cl:1])[CH3:17])=[CH:20][CH:21]=1

参加物

5

反応物 3

HCID 142824-AcetylpyridineHCID 312751,4-DioxaneHCID 456735Acetic acid, (2,4,5-trichlorophenoxy)-, hydrazide

生成物 1

HCID 3285123HCID 3285123、化合物収率 83.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 5.39 gm (0.02 mole) of 2,4,5-trichlorophenoxyacetic acid hydrazide, 2.42 gm (0.02 mole) of 4-acetylpyridine, 125 ml of dioxane and 2 ml of acetic acid is refluxed 4 hr. The hot solution is filtered. The filtrate is diluted with water until cloud point. The mixture is cooled to room temperature and then chilled in the refrigerator. The product is collected to yield 6.24 gm (83%) of the title compound having a melting point of 227.4° C. (decomp).

後処理

  1. filtrationThe hot solution is filtered
  2. additionThe filtrate is diluted with water until cloud point
  3. temperaturechilled in the refrigerator
  4. customThe product is collected

出典と根拠

ORDレコード
ord-7746501c1fdb4eeb8fdbd0052e01e4bb
出典データセット
uspto-grants-1991_04
特許番号
US05011932

反応ノート

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