Ethanol → Acetic acid [1-(6-methyl-3-pyridinyl)ethylidene]hydrazide

HRID 1085971ノート

反応式

HRID 1085971 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][N:3]=1.[C:11]([NH:14][NH2:15])(=[O:13])[CH3:12].C(O)C>CCCCCC>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([C:8](=[N:15][NH:14][C:11](=[O:13])[CH3:12])[CH3:9])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 702EthanolHCID 14039AcetohydrazideHCID 952923-Acetyl-6-methylpyridine

生成物 1

HCID 53804808Acetic acid [1-(6-methyl-3-pyridinyl)ethylidene]hydrazide収率 83%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A mixture of 6.76 gm (0.05 mole) of 2-methyl-5-acetylpyridine, 3.7 gm (0.05 mole) of acetic acid hydrazide and 100 ml of ethanol was refluxed 5 hr. The solution was diluted with Skellysolve B until cloudy. The mixture was cooled to room temperature and then chilled in the freezer. The product was collected, washed with Skellysolve B and dried to afford 7.93 gm (83%) of the title compound having a melting point of 178.5° C.

後処理

  1. temperaturewas refluxed 5 hr
  2. temperaturechilled in the freezer
  3. customThe product was collected
  4. washwashed with Skellysolve B
  5. customdried

出典と根拠

ORDレコード
ord-948ebe38f64748edb27c9769bb893aaa
出典データセット
uspto-grants-1991_04
特許番号
US05011932

反応ノート

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