4-Phenoxyphenol → 1-(2-Fluoroethoxy)-4-phenoxybenzene

HRID 1086011

反応式

HRID 1086011 の反応式
[H-].[Na+].[O:3]([C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CS(O[CH2:22][CH2:23][F:24])(=O)=O>CN(C)C=O>[F:24][CH2:23][CH2:22][O:16][C:13]1[CH:12]=[CH:11][C:10]([O:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 132544-PhenoxyphenolHCID 24758Sodium hydrideHCID 680342-Fluoroethyl methanesulfonate

生成物 1

HCID 156713911-(2-Fluoroethoxy)-4-phenoxybenzene収率 86.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a suspension of sodium hydride (60% oil dispersion; 4.0 g) in N,N-dimethylformamide (100 ml), 4-phenoxyphenol (18.6 g) was added at a temperature of 0 to 5° C., and the resultant suspension was stirred at room temperature for 1 hour. 2-Fluoroethyl methanesulfonate (14.2 g) was added thereto. The resulting mixture was stirred at room temperature for 12 hours. The reaction mixture was subjected to post-treatment as in Example 1 to give 1-(2-fluoroethoxy)-4-phenoxybenzene (Compound No. 22) (20.0 g). nD25.0 1.5622.

後処理

  1. additionwas added at a temperature of 0 to 5° C.

出典と根拠

ORDレコード
ord-ebd1ed430dc94dadaa8a3438acb2faab
出典データセット
uspto-grants-1991_04
特許番号
US05012004

関連ノート

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