反応式
NC1C(Cl)=CC(C(NCCN(CC)CC)=[O:7])=C(OCCSC)C=1.[NH2:24][C:25]1[C:40]([Cl:41])=[CH:39][C:28]([C:29]([NH:31][CH2:32][CH2:33][N:34]([CH2:37][CH3:38])[CH2:35][CH3:36])=[O:30])=[C:27]([O:42][CH2:43][CH2:44][CH2:45][CH2:46][S:47][CH3:48])[CH:26]=1>>[NH2:24][C:25]1[C:40]([Cl:41])=[CH:39][C:28]([C:29]([NH:31][CH2:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38])=[O:30])=[C:27]([O:42][CH2:43][CH2:44][CH2:45][CH2:46][S:47]([CH3:48])=[O:7])[CH:26]=1参加物
3
実験手順
The general procedure from Example 21 is repeated except that the 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[2-(methylthio)ethoxy]benzamide utilized therein was replaced with the product from Step A to give the title compound in 78% yield after chromatography on silica and crystallization from methylene chloride-ether, as a solid, mp. 80°-83° C.
出典と根拠
- ORDレコード
- ord-3736ffac7be74bff8be8bf8d8d0b9c07
- 出典データセット
- uspto-grants-1991_04
- 特許番号
- US05011992
関連ノート
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