Tetrahydrofuran → 4-Ethyl-5,5-bis(4-fluorophenyl)-2,4-pentadienal

反応式

C([Li])CCC.C(NC1CCCCC1)(C)C.[CH2:16]([C:18](=[C:21]([C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1)[C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)C=O)[CH3:17].[O:36]1C[CH2:39][CH2:38][CH2:37]1>>[CH2:16]([C:18](=[C:21]([C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)[C:29]1[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=1)[CH:39]=[CH:38][CH:37]=[O:36])[CH3:17]

参加物

反応物 4

HCID 8028Tetrahydrofuran2 回

HCID 62386Cyclohexylisopropylamine

HCID 151330552-Ethyl-3,3-bis(4-fluorophenyl)-2-propenal

HCID 178418339Butyllithium

生成物 1

HCID 541186354-Ethyl-5,5-bis(4-fluorophenyl)-2,4-pentadienal

反応条件

温度: -40 °C

実験手順

Butyl lithium (25.7 mL of 2.1M solution, 54 mmol) was added to a solution of N-isopropylcyclohexylamine in 30 mL tetrahydrofuran at -10° C. After stirring for 30 minutes and cooling to -40° C., N-ethylidenecyclohexamine (27 mL of 2M solution, 54 mmol) was added and the solution stirred for 30 minutes. The solution was further cooled to -70° C. and 2-ethyl-3,3-bis(4-fluorophenyl)- 2-propenal(4.9 g, 18 mmol) in 40 mL of tetrahydrofuran was added. The mixture was stirred for 5 hours and quenched with water. The mixture was extracted with diethyl ether, the extracts dried over magnesium sulfate and concentrated in vacuo. The residue was stirred with a mixture of 100 mL of benzene, 40 mL of water and 60 mL of acetic acid for 16 hours and diluted with 1.50 mL of water. The organic layer was separated, washed with saturated sodium bicarbonate solution, dried with magnesium sulfate and concentrated in vacuo. The residue was crystallized from petroleum ether to give 3.45 g of the title compound; m.p. =98°-99.5° C.