Z-Pro-Val-OtBu → Z-Pro-val-OH
反応式
[N:1]1([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:19][CH2:18][CH2:17][C@H:2]1[C:3]([NH:5][C@H:6]([C:10]([O:12]C(C)(C)C)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4]>FC(F)(F)C(O)=O>[N:1]1([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:19][CH2:18][CH2:17][C@H:2]1[C:3]([NH:5][C@H:6]([C:10]([OH:12])=[O:11])[CH:7]([CH3:8])[CH3:9])=[O:4]参加物
3
試薬・触媒・溶媒 1
実験手順
2.63 g of Z-Pro-Val-OtBu are dissolved in 20 ml of 90% trifluoroacetic acid. The mixture is left to stand at room temperature for one hour, and is concentrated. The residue is triturated with water. The precipitate is filtered off with suction and dried over P2O5. For further purification, the product is chromatographed on silica gel in CH2Cl2 /CH30H/petroleum ether/acetic acid/water 18:1:2:0.1:0.1.
後処理
- waitThe mixture is left
- concentrationis concentrated
- customThe residue is triturated with water
- filtrationThe precipitate is filtered off with suction
- dry with material