HCID 178455928、化合物 → Fmoc-Arg-Ile-OH

HRID 1086125ノート

反応式

HRID 1086125 の反応式
[NH:1]([C:25]([O:27][CH2:28][CH:29]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]2[C:30]1=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:26])[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20]C(C)(C)C)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8]>FC(F)(F)C(O)=O>[NH:1]([C:25]([O:27][CH2:28][CH:29]1[C:30]2[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:36]2[C:41]1=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:26])[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([OH:20])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

参加物

3

反応物 1

HCID 178455928HCID 178455928、化合物

生成物 1

HCID 178455927Fmoc-Arg-Ile-OH

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

15.8 g of Fmoc-Arg-Ile-OtBu are dissolved in 150 ml of 90% strength aqueous trifluoroacetic acid. The solution is left to stand at room temperature for 1 hour, and is concentrated. The residue is triturated twice with diethyl ether, the ether being decanted off each time. Water is added to the residue, and the pH is adjusted to with saturated NaHCO3 solution. The precipitate is filtered off with suction and dried.

後処理

  1. waitThe solution is left
  2. concentrationis concentrated
  3. customThe residue is triturated twice with diethyl ether
  4. customthe ether being decanted off each time
  5. additionWater is added to the residue
  6. filtrationThe precipitate is filtered off with suction
  7. customdried

出典と根拠

ORDレコード
ord-7cc252e9a0024683826e317a26012343
出典データセット
uspto-grants-1991_04
特許番号
US05011825

反応ノート

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