1,6-Dibromohexane → 2-[3-[(6-Bromohexyl)oxy]propyl]thiophene
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][CH2:8][OH:9].[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br.[OH-].[Na+]>O>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:9][CH2:8][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 2-thiphenepropanol (5 g), 1,6-dibromohexane (25 g), 50% aqueous sodium hydroxide (25 ml) and TAB (500 mg) was stirred at room temperature overnight. Water (100 ml) was added over and the mixture was extracted with ether (2×100 ml). The organic layer was dried and concentrated to an oil which was purified by FCC eluting with hexane to give the title compound as a colourless oil (6.6 g). T.l.c. (hexane-diethyl ester 9:1) Rf 0.50.
後処理
- extractionwas extracted with ether (2×100 ml)
- customThe organic layer was dried
- concentrationconcentrated to an oil which
- customwas purified by FCC
- washeluting with hexane
出典と根拠
- ORDレコード
- ord-1f61b55ea6764fe0bf4c543610b6106a
- 出典データセット
- uspto-grants-1991_07
- 特許番号
- US05032609
反応ノート
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