2-Chloroadenosine → HCID 15690127、化合物

HRID 1087006

反応式

HRID 1087006 の反応式
Cl[C:2]1[N:3]=[C:4]([NH2:20])[C:5]2[N:6]=[CH:7][N:8]([C:18]=2[N:19]=1)[C@@H:9]1[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]1[OH:11].[CH2:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH:22]1[NH2:30].C(N(C(C)C)CC)(C)C.C(O)CC(C)C>C(OCC)(=O)C>[CH2:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH:22]1[NH:30][C:2]1[N:3]=[C:4]([NH2:20])[C:5]2[N:6]=[CH:7][N:8]([C:18]=2[N:19]=1)[C@@H:9]1[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]1[OH:11]

参加物

6

反応物 4

HCID 89742-ChloroadenosineHCID 31260Isoamyl AlcoholHCID 763102-AminoindaneHCID 81531Diisopropylethylamine

生成物 1

HCID 15690127HCID 15690127、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 1.0 g of 2-chloroadenosine, 1.2 g of 2-indanylamine, and 1.6 ml of diisopropylethylamine and 1.0 ml of isoamyl alcohol is refluxed for 16 hours. The reaction mixture is diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. After drying over magnesium sulfate the solvent is removed in vacuo and the residue is chromatographed on silica gel with 10:1 methylene chloride/ammonia saturated methanol as the eluent. The resulting product is recrystallized from methanol to afford 2-(2-indanylamino)-adenosine melting at 129°-132°.

後処理

  1. temperatureis refluxed for 16 hours
  2. washwashed with saturated sodium bicarbonate solution
  3. dry with materialAfter drying over magnesium sulfate the solvent
  4. customis removed in vacuo
  5. customthe residue is chromatographed on silica gel with 10:1 methylene chloride/ammonia saturated methanol as the eluent
  6. customThe resulting product is recrystallized from methanol

出典と根拠

ORDレコード
ord-82de9719748d4c5bb7e8257c39e9438c
出典データセット
uspto-grants-1991_07
特許番号
US05034381

関連ノート

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