Methylamine → 1-(6-Chloro-3-pyridylmethyl)-1,3-dimethyl-2-nitroguanidine
反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH3:17])[C:10](=[N:13][N+:14]([O-:16])=[O:15])SC)=[CH:4][CH:3]=1.[CH3:18][NH2:19]>C(#N)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH3:17])[C:10]([NH:19][CH3:18])=[N:13][N+:14]([O-:16])=[O:15])=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
A mixture of 0.82g of 1-(6-chloro-3-pyridylmethyl)-1,2-dimethyl-3-nitroisothiourea, 0.464g of 40% methylamine aqueous solution and 10ml of acetonitrile was stirred for 2 hours at 70° C., and concentrated. The residue was purified by a column chromatography [developing solution: dichloromethane-methanol [10:1]) to afford 0.56g of 1-(6-chloro-3-pyridylmethyl)-1,3-dimethyl-2-nitroguanidine (Compound No. 8).
後処理
- concentrationconcentrated
- customThe residue was purified by a column chromatography [
出典と根拠
- ORDレコード
- ord-25613c25eac14f9eaf2fa7da592a1d7e
- 出典データセット
- uspto-grants-1991_07
- 特許番号
- US05034404
反応ノート
読み込み中…