Acetic Anhydride → N-(3-Chlorophenyl)acetamide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=1)(=[O:11])[CH3:10]参加物
3
反応条件
- 温度
- 90 °C
実験手順
To 3-chloroaniline (10 g, 0.078 mol) was added portionwise acetic anhydride (32 g, 0.314 mol) in such a manner as to keep the temperature of the reaction mixture below 85° C. The reaction mixture was then stirred at 90° C. for 4 hours and then cooled to room temperature. The reaction mixture was then poured carefully into ice water, extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed, yielding 30 g of N-acetyl-3-chloroaniline.
後処理
- customthe temperature of the reaction mixture below 85° C
- temperaturecooled to room temperature
- extractionextracted with ethyl acetate
- dry with materialdried over sodium sulfate
- customThe solvent was removed
出典と根拠
- ORDレコード
- ord-c22f2be1bb7d4cd7a687f81dea07ae3a
- 出典データセット
- uspto-grants-1991_07
- 特許番号
- US05034410
反応ノート
読み込み中…