HCID 21273587、化合物 → HCID 178429718、化合物

HRID 1087443ノート

反応式

HRID 1087443 の反応式
[SH:1][C:2]1[N:7]2[N:8]=[C:9]([C:11](OC)=[O:12])[N:10]=[C:6]2[N:5]=[C:4]([CH3:15])[CH:3]=1.[H-].C([Al+]CC(C)C)C(C)C.CCCCCC>O1CCCC1>[SH:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][OH:12])[N:10]=[C:6]2[N:5]=[C:4]([CH3:15])[CH:3]=1

参加物

4

反応物 2

HCID 21273587HCID 21273587、化合物HCID 178499048HCID 178499048、化合物

生成物 1

HCID 178429718HCID 178429718、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2.24 g of methyl 7-mercapto-5-methyl-s-triazolo[1,5-a]-pyrimidine-2-carboxylate were suspended in 350 ml of tetrahydrofuran and treated at 2° within 15 minutes with 40 ml of a 1M diisobutylaluminium hydride/hexane solution. The reaction mixture was stirred at 2° for 10 minutes and subsequently treated with ice. The reaction mixture was concentrated extensively, the residue was taken up in 30 ml of water, and the solution was acidified to pH 1.2 with concentrated hydrochloric acid. The solid was collected by filtration and dried in a high vacuum. There was obtained 7-mercapto-5-methyl-s-tria-zolo[1,5-a]pyrimidine-2-methanol of melting point 233° (dec.).

後処理

  1. additionsubsequently treated with ice
  2. concentrationThe reaction mixture was concentrated extensively
  3. filtrationThe solid was collected by filtration
  4. customdried in a high vacuum

出典と根拠

ORDレコード
ord-7726262c3a3e4bf5a62cd85bdb16f84d
出典データセット
uspto-grants-1991_07
特許番号
US05036064

反応ノート

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