2-Amino-6-methylbenzothiazole → 2-methoxy-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide

HRID 1087471

反応式

HRID 1087471 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][O:13][CH2:14][C:15](Cl)=[O:16]>N1C=CC=CC=1>[CH3:12][O:13][CH2:14][C:15]([NH:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:5]=2[N:6]=1)=[O:16]

参加物

4

反応物 2

HCID 173352-Amino-6-methylbenzothiazoleHCID 96623Methoxyacetyl chloride

生成物 1

HCID 8365022-methoxy-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Amino-6-methylbenzothiazole (4.9 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting oil is solidified with addition of water. The obtained solids are filtered off and washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (4.1 g) having the following physical properties.

後処理

  1. distillationthe solvent is distilled off
  2. additionThe resulting oil is solidified with addition of water
  3. filtrationThe obtained solids are filtered off
  4. washwashed with water
  5. dry with materialwith diethyl ether, dried
  6. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-7d19eba1315d487793a9ea0570984494
出典データセット
uspto-grants-1991_07
特許番号
US05036086

関連ノート

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