Amino-6-ethoxybenzothiazole, 2- → N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

HRID 1087472

反応式

HRID 1087472 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][O:15][CH2:16][C:17](Cl)=[O:18]>N1C=CC=CC=1>[CH2:12]([O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:1][C:17](=[O:18])[CH2:16][O:15][CH3:14])[S:3][C:4]=2[CH:10]=1)[CH3:13]

参加物

4

反応物 2

HCID 7192Amino-6-ethoxybenzothiazole, 2-HCID 96623Methoxyacetyl chloride

生成物 1

HCID 652526N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Amino-6-ethoxybenzothiazole (5.8 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting solids are washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

後処理

  1. distillationthe solvent is distilled off
  2. washThe resulting solids are washed with water
  3. dry with materialwith diethyl ether, dried
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-f05414f5b307422c99104486583775b9
出典データセット
uspto-grants-1991_07
特許番号
US05036086

関連ノート

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