Isoamyl Nitrite → 2-Hydroxy-4-nitrobenzene diazonium triflate

HRID 1087611ノート

反応式

HRID 1087611 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11].[F:12][C:13]([F:19])([F:18])[S:14]([OH:17])(=[O:16])=[O:15].[N:20](OCCC(C)C)=O>CO>[O-:17][S:14]([C:13]([F:19])([F:18])[F:12])(=[O:16])=[O:15].[OH:11][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[N+:1]#[N:20]

参加物

5

反応物 3

HCID 8053Isoamyl NitriteHCID 62406Trifluoromethanesulfonic acidHCID 49847212-Amino-5-Nitrophenol

生成物 1

HCID 867449522-Hydroxy-4-nitrobenzene diazonium triflate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To an ice cooled solution containing 5 parts of 2-amino-5-nitrophenol and 9.6 parts of trifluoromethane sulfonic acid in 150 parts of methanol was slowly added 3.9 parts of isoamyl nitrite to complete diazotization. The solution was filtered and the filtrate was poured into 700 parts of ethyl ether. The precipitate was collected, washed with ether and dried under vacuum to give 4.5 parts of product with purity >95%.

後処理

  1. filtrationThe solution was filtered
  2. additionthe filtrate was poured into 700 parts of ethyl ether
  3. customThe precipitate was collected
  4. washwashed with ether
  5. customdried under vacuum
  6. customto give 4.5 parts of product with purity >95%

出典と根拠

ORDレコード
ord-085549e1130a4fcfb035d38b8d411f63
出典データセット
uspto-grants-1991_07
特許番号
US05036142

反応ノート

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