Hydrochloric Acid → HCID 14556333、化合物

反応式

[C:1]([C:5]1[CH:15]=[CH:14][C:8]2[N:9]([CH3:13])[C:10](=[O:12])[O:11][C:7]=2[CH:6]=1)(=[O:4])[CH2:2][CH3:3].[F:16][C:17]([F:31])([F:30])[C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1.Cl.[CH2:33](O)CC>>[CH3:13][N:9]1[C:8]2[CH:14]=[CH:15][C:5]([C:1](=[O:4])[CH:2]([CH3:33])[CH2:3][N:27]3[CH2:28][CH2:29][N:24]([C:20]4[CH:21]=[CH:22][CH:23]=[C:18]([C:17]([F:16])([F:30])[F:31])[CH:19]=4)[CH2:25][CH2:26]3)=[CH:6][C:7]=2[O:11][C:10]1=[O:12]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 10311-Propanol

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazine

HCID 3043000JPB 5

生成物 1

HCID 14556333HCID 14556333、化合物

実験手順

0.025 mole of 6-propionyl-3-methylbenzoxazolinone, described in French Patent No. 73/23,280, and 0.038 mole of 1-(3-trifluoromethylphenyl)piperazine are dissolved in 150 cm3 of propanol in a 250-cm3 groundnecked flask equipped with a reflux condenser and a magnetic stirrer. 0.038 mole of trioxymethylene and 1.5 cm3 of concentrated hydrochloric acid are added. The mixture is heated to reflux for 72 hours. The precipitate formed is drained, washed with acetone, suspended in water and alkalinized with sodium hydroxide. The mixture is extracted several times with chloroform, the organic phases are combined, dried over calcium chloride, filtered and evaporated on a water bath under vacuum and the residue is recrystallized in propanol.