5-Methyl-2-hexanone → HCID 22163835、化合物

HRID 1087783

反応式

HRID 1087783 の反応式
[OH:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=O)[N:3]1[C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[N:15][C:16]([CH3:22])=[CH:17][CH:18]=2)[N:13]=1.[H-].[Na+].[CH3:25][CH:26]([CH3:32])[CH2:27][CH2:28][C:29](=[O:31])[CH3:30]>>[CH3:22][C:16]1[N:15]=[C:14]2[C:19]([CH:20]=[CH:21][C:12]([N:3]3[CH:4]([CH2:30][C:29](=[O:31])[CH2:28][CH2:27][CH:26]([CH3:32])[CH3:25])[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[C:2]3=[O:1])=[N:13]2)=[CH:18][CH:17]=1

参加物

4

反応物 3

HCID 80345-Methyl-2-hexanoneHCID 24758Sodium hydrideHCID 199004392-(7-Methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone

生成物 1

HCID 22163835HCID 22163835、化合物収率 9.5%

実験手順

Working in a manner similar to that described in Example 1, but starting with 3-hydroxy-2-(7-methyl-1,8-naphthyridin-2-yl)-1-isoindolinone (7.9 g), an oily suspension (50% by weight; 2 g) of sodium hydride and 5-methyl-2-hexanone (6.2 g), and stirring the reaction mixture for 3 hours at a temperature in the region of -5° C., and then for 2 hours at 0° C., 2-(7-methyl-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone (1 g), m.p. 155° C., is obtained after recrystallization in ethanol.

出典と根拠

ORDレコード
ord-73581e2d31fc402997533ab895fa3855
出典データセット
uspto-grants-1990_10
特許番号
US04960779

関連ノート

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