Sodium Hydroxide → Minoxidil

HRID 1087883

反応式

HRID 1087883 の反応式
C([NH:4][C:5]1[N:10]([O:11]C(=O)C)[C:9](=[NH:15])[N:8]=[C:7]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:6]=1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:4][C:5]1[N:10]([OH:11])[C:9](=[NH:15])[N:8]=[C:7]([N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 140353009HCID 140353009、化合物

生成物 1

HCID 4201Minoxidil

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.0 g (3.4 mmoles) of 6-acetamido-1-acetoxy-1,2-dihydro-2-imino-4-piperidinopyrimidine prepared as described in Example 7 is dissolved in a mixture containing 20 ml of ethanol and 5 ml of 1N aqueous sodium hydroxide solution, the mixture is refluxed for 30 minutes, then evaporated under reduced pressure. Taking up the residue in 10 ml of water, the crystals are filtered, washed with water and dried to give the aimed compound in a yield of 0.54 g (76%), which shows no melting point depression when mixed with the product of Example 1.

後処理

  1. dissolutionis dissolved in a mixture
  2. temperaturethe mixture is refluxed for 30 minutes
  3. customevaporated under reduced pressure
  4. filtrationthe crystals are filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-bd0a4a8219f34b3488950ee14ff77a09
出典データセット
uspto-grants-1990_10
特許番号
US04960888

関連ノート

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