N-[4-(2-fluoroethoxy)phenyl]acetamide → HCID 15058655、化合物

HRID 1087885ノート

反応式

HRID 1087885 の反応式
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=O)[CH3:13])=[CH:7][CH:6]=1.[H-].COCCO[Al+]OCCOC.[Na+].[H-]>O1CCCC1.C1(C)C=CC=CC=1.C(OCC)(=O)C.O>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH2:12][CH3:13])=[CH:7][CH:6]=1

参加物

7

反応物 2

HCID 3423433N-[4-(2-fluoroethoxy)phenyl]acetamideHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

生成物 1

HCID 15058655HCID 15058655、化合物収率 58.2%

試薬・触媒・溶媒 4

HCID 962Water溶媒HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 3.0 grams (0.015 mole) of 4-acetamidophenyl 2-fluoroethyl ether in 15 ml of dry tetrahydrofuran was added dropwise to a stirred solution of 15 ml of a 3.4 M solution of sodium bis(2-methoxyethoxy)aluminium hydride (Red-Al®) in toluene and 50 ml of dry tetrahydrofuran. The reaction mixture was stirred at room temperature for approximately 18 hours. The mixture was quenched with 1 ml of water and was filtered. The filtrate was evaporated under reduced pressure leaving a dark liquid which solidified upon standing. This solid was dissolved in ethyl acetate to which a small amount of water was added. A small amount of precipitate formed from which the organic solution was decanted. The organic solution was evaporated under reduced pressure leaving a dark liquid residue. This residue was purified by column chromatography on silica gel followed by distillation under reduced pressure to yield 1.6 grams of 4-(ethylamino)phenyl 2-fluoroethyl ether as a solid.

後処理

  1. customThe mixture was quenched with 1 ml of water
  2. filtrationwas filtered
  3. customThe filtrate was evaporated under reduced pressure
  4. customleaving a dark liquid which
  5. additionwas added
  6. customA small amount of precipitate formed from which the organic solution
  7. customwas decanted
  8. customThe organic solution was evaporated under reduced pressure
  9. customleaving a dark liquid residue
  10. customThis residue was purified by column chromatography on silica gel
  11. distillationfollowed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-91d889fc7be549e59c8435d2a94b999f
出典データセット
uspto-grants-1990_10
特許番号
US04960884

反応ノート

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