2-Hydroxy-1-naphthaldehyde → 2-(2-Fluoroethoxy)-1-hydroxymethylnaphthalene

HRID 1087901

反応式

HRID 1087901 の反応式
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]=1[CH:15]=[O:16].OC1C=CC2C(=CC=CC=2)C=1C=O.[BH4-].[Na+]>C(O)C.O>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]=1[CH2:15][OH:16]

参加物

6

反応物 3

HCID 128192-Hydroxy-1-naphthaldehydeHCID 4311764Sodium borohydrideHCID 150587342-(2-Fluoroethoxy)-1-naphthaldehyde

生成物 1

HCID 150587332-(2-Fluoroethoxy)-1-hydroxymethylnaphthalene収率 45.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 2.5 grams (0.012 mole) of 2-(2-fluoroethoxy)-1-naphthaldehyde (prepared by the method of Example 1 from 2-hydroxy-1-naphthaldehyde) and 0.6 gram (0.015 mole) of sodium borohydride in 35 ml of ethanol was stirred at room temperature for 24 hours. The mixture was diluted with water and extracted with diethyl ether. The extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure to yield 1.2 gram of 2-(2-fluoroethoxy)-1-hydroxymethylnaphthalene as a solid.

後処理

  1. extractionextracted with diethyl ether
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-8c2fb2ca43f34f948047a93f82ef72e7
出典データセット
uspto-grants-1990_10
特許番号
US04960884

関連ノート

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