Ethanol → 6-Ethoxyimidazo[1,2-b]pyridazine

HRID 1088242ノート

反応式

HRID 1088242 の反応式
[Na].Cl[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1.[CH2:12]([OH:14])[CH3:13]>>[CH2:12]([O:14][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1)[CH3:13]

参加物

4

反応物 3

HCID 702EthanolHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 5360545Sodium

生成物 1

HCID 200766186-Ethoxyimidazo[1,2-b]pyridazine

実験手順

Sodium metal (0.55 g) is dissolved in 30 ml of ethanol and, to the solution, is added 3 g of 6-chloroimidazo[1,2-b]pyridazine and the mixture is heated under reflux for 3 hours. The solvent is then evaporated off under reduced pressure and the residue is dissolved in water and the mixture is extracted with methylene chloride. The extracts are combined, washed with saturated solution of sodium chloride and dried over MgSO4. The solvent is then evaporated to give 3.3 g of the title compound as colorless crystals.

後処理

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. customThe solvent is then evaporated off under reduced pressure
  4. dissolutionthe residue is dissolved in water
  5. extractionthe mixture is extracted with methylene chloride
  6. washwashed with saturated solution of sodium chloride
  7. dry with materialdried over MgSO4
  8. customThe solvent is then evaporated

出典と根拠

ORDレコード
ord-43663e281df34953b22415d732014315
出典データセット
uspto-grants-1990_10
特許番号
US04962100

反応ノート

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