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4,6-Dimethyl-2-(4-nitrobenzyloxycarbonylthio)pyrimidine → (2R,4R)-1-p-nitrobenzyloxycarbonyl-2-(4-t-butoxycarbonylbutyl)-4-t-butyldimethylsilyloxypyrrolidine

HRID 1088282
ノート
印刷プレビュー

反応式

HRID 1088282 の反応式
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]([CH2:8][O:9][C:10](SC2N=C(C)C=C(C)N=2)=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:23]([O:27][C:28]([CH2:30][CH2:31][CH2:32][CH2:33][C@@H:34]1[CH2:38][C@@H:37]([O:39][Si:40]([C:43]([CH3:46])([CH3:45])[CH3:44])([CH3:42])[CH3:41])[CH2:36][NH:35]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>O1CCCC1.C(OCC)(=O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][O:9][C:10]([N:35]2[CH2:36][C@H:37]([O:39][Si:40]([C:43]([CH3:46])([CH3:45])[CH3:44])([CH3:42])[CH3:41])[CH2:38][C@H:34]2[CH2:33][CH2:32][CH2:31][CH2:30][C:28]([O:27][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:29])=[O:11])=[CH:21][CH:22]=1)([O-:3])=[O:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 135043164,6-Dimethyl-2-(4-nitrobenzyloxycarbonylthio)pyrimidineHCID 15671521(2R,4R)-2-(4-t-butoxycarbonylbutyl)-4-t-butyldimethylsilyloxypyrrolidine

生成物 1

HCID 15671522(2R,4R)-1-p-nitrobenzyloxycarbonyl-2-(4-t-butoxycarbonylbutyl)-4-t-butyldimethylsilyloxypyrrolidine

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857
Ethyl Acetate
溶媒

実験手順

S-p-Nitrobenzyloxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine (719 mg) was added to 770 mg of (2R,4R)-2-(4-t-butoxycarbonylbutyl)-4-t-butyldimethylsilyloxypyrrolidine in 7 ml of tetrahydrofuran and stirred at room temperature for 2 hours. The reaction mixture was diluted with ethyl acetate, washed successively with brine, dilute hydrochloric acid and brine, dried over anhydrous sodium sulfate and distilled to remove the solvent. The residue was purified by silica gel chromatography to obtain (2R,4R)-1-p-nitrobenzyloxycarbonyl-2-(4-t-butoxycarbonylbutyl)-4-t-butyldimethylsilyloxypyrrolidine.

後処理

  1. washwashed successively with brine, dilute hydrochloric acid and brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. distillationdistilled
  4. customto remove the solvent
  5. customThe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-7dde82a565624ae0977c5122641c87fc
出典データセット
uspto-grants-1990_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04962103

反応ノート

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