N-(1,1-Dimethylethyl)-1,3-propanediamine → N-[3-[(1,1-Dimethylethyl)amino]propyl]-4,5-diphenyl-1H-imidazole-1-acetamide

HRID 1088295

反応式

[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:18][C:19]([O:21]CC)=O)[C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:24]([NH:28][CH2:29][CH2:30][CH2:31][NH2:32])([CH3:27])([CH3:26])[CH3:25].[H-].[H-].[H-].[H-].[Li+].[Al+3].C(NCCC#N)(C)(C)C>C1COCC1.C(Cl)Cl.O>[CH3:25][C:24]([NH:28][CH2:29][CH2:30][CH2:31][NH:32][C:19](=[O:21])[CH2:18][N:10]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=[CH:9]1)([CH3:27])[CH3:26]

参加物

反応条件

温度: 100 °C

実験手順

A mixture of 7.0 g (23 mmol) of ethyl 4,5-diphenyl-1H-imidazole-1-acetate of example 1 and 4.5 g (34.6 mmol) of 3-(t-butylamino)propylamine, conveniently made by LAH reduction of 3-(t-butylamino)propionitrile in THF, was heated at 100° C. for 8 hr. The residue was distributed between water and methylene chloride, and the methylene chloride layer was dried over MgSO4 and stripped. The residue was recrystallized from ether and then cyclohexane to yield 4.5 g of product, mp 94°-96° C.

後処理

dry with materialthe methylene chloride layer was dried over MgSO4
customThe residue was recrystallized from ether

出典と根拠

ORDレコード: ord-c994c8e965704442a0afefbd84abbe5a
出典データセット: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04962120

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 3

反応条件

実験手順

後処理

出典と根拠

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