Ethanol → 1,4-Diethyl 2-formylbutanedioate

HRID 1088296

反応式

HRID 1088296 の反応式
[CH2:1]([OH:3])C.[Na].[C:5]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].C(OCC)=O>C1(C)C=CC=CC=1.O>[CH:1]([CH:6]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:5]([O:14][CH2:15][CH3:16])=[O:13])=[O:3]

参加物

7

反応物 4

HCID 702EthanolHCID 8025Ethyl formateHCID 31249Diethyl SuccinateHCID 5360545Sodium

生成物 1

HCID 2315001,4-Diethyl 2-formylbutanedioate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

Ethanol (20 cm3) was added portionwise to a suspension of finely divided sodium (10.0 g) in dry toluene (100 cm3). On completion of the addition the mixture was heated for 3.5 hours at 80° C. To the resulting yellow suspension, cooled to 20° C., was added dropwise, over a period of 1 hour, a mixture of diethyl succinate (70.0 g) and ethyl formate (35.0 g), whilst the temperature of the mixture was maintained in the range 20° to 30° C. The mixture was kept at the ambient temperature for 16 hours after which water (100 cm3) was added carefully.

後処理

  1. additionOn completion of the addition the mixture
  2. temperatureTo the resulting yellow suspension, cooled to 20° C.
  3. additionwas added dropwise, over a period of 1 hour
  4. temperaturewhilst the temperature of the mixture was maintained in the range 20° to 30° C

出典と根拠

ORDレコード
ord-f2be7aaf87b242a2a6134e8fe8001b38
出典データセット
uspto-grants-1990_10
特許番号
US04962109

関連ノート

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