Benzoyl Peroxide → (7-Bromo-quinolin-2-yl)methylbromide
反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][CH:3]=1.[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][Br:13])=[N:9]2)=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 220 g 7-bromoquinaldine, 180 g N-bromosuccinimide and 1 g dibenzoylperoxide in CCl4 (1 L) was illuminated with a 275 W sun lamp at reflux for 12 hours. The reaction mixture was cooled and directly chromatographed on 2 kg silica gel. Elution with toluene afforded the title compound which was used as is for the next step.
後処理
- customwas illuminated with a 275 W sun lamp
- temperatureat reflux for 12 hours
- temperatureThe reaction mixture was cooled
- customdirectly chromatographed on 2 kg silica gel
- washElution with toluene
出典と根拠
- ORDレコード
- ord-ca978d4c001a4ffc80af50722d6f7f92
- 出典データセット
- uspto-grants-1990_10
- 特許番号
- US04962203
反応ノート
読み込み中…