Water → 1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-2-[[6-[3-[3-(phenylmethoxy)-2-pyridinyl]propoxy]hexyl](phenylmethyl)amino]ethanone

HRID 1088720ノート

反応式

HRID 1088720 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH2:12][OH:13])[CH:6]=1)=[O:4].[C:14]1([CH2:20][O:21][C:22]2[C:23]([CH2:28][CH2:29][CH2:30][O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][NH:38][CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)=[N:24][CH:25]=[CH:26][CH:27]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O.CCOCC>C1COCC1>[OH:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:38]([CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][O:31][CH2:30][CH2:29][CH2:28][C:23]2[C:22]([O:21][CH2:20][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:27][CH:26]=[CH:25][N:24]=2)[CH2:39][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)=[CH:6][C:7]=1[CH2:12][OH:13]

参加物

6

反応物 4

HCID 962WaterHCID 3283Diethyl EtherHCID 113340552-Bromo-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethan-1-oneHCID 54019079N-[6-[3-[3-(phenylmethoxy)-2-pyridinyl]propoxy]hexyl]benzenemethanamine

生成物 1

HCID 221617531-[4-Hydroxy-3-(hydroxymethyl)phenyl]-2-[[6-[3-[3-(phenylmethoxy)-2-pyridinyl]propoxy]hexyl](phenylmethyl)amino]ethanone収率 56.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanone (460 mg), N-[6-[3-[3-(phenylmethoxy)-2-pyridinyl]propoxy]hexyl]benzenemethanamine (800 mg) and DEA (485 mg) in THF (15 ml) was left at room temperature overnight. Water (30 ml) and ether (30 ml) were added, the phases were separated and the organic layer was re-extracted with ether (50 ml). The combined extracts were washed with water and brine, dried and concentrated to an oil which was purified by FCC eluting with ethyl acetate/triethylamine (99:1) followed by ethyl acetate/methanol/triethylamine (90:10:1) to give the title compound as an orange oil (620 mg), t.l.c. (ethyl acetate/methanol/triethylamine 80:20:1) Rf 0.66.

後処理

  1. customthe phases were separated
  2. extractionthe organic layer was re-extracted with ether (50 ml)
  3. washThe combined extracts were washed with water and brine
  4. customdried
  5. concentrationconcentrated to an oil which
  6. customwas purified by FCC
  7. washeluting with ethyl acetate/triethylamine (99:1)

出典と根拠

ORDレコード
ord-1a0a2b06a7af47bd8738b09c5944e96a
出典データセット
uspto-grants-1990_10
特許番号
US04963564

反応ノート

読み込み中…