Sodium Hydroxide → Quinolin-8-ylmethanol

HRID 1088785ノート

反応式

HRID 1088785 の反応式
C([O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[CH:13][CH:12]=[CH:11]2)(=O)C.[OH-].[Na+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[CH:13][CH:12]=[CH:11]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 150531408-Quinolinemethanol,acetate(ester)

生成物 1

HCID 594412Quinolin-8-ylmethanol収率 96.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 8-acetoxymethylquinoline (12.07 g) in methanol (80 ml) was added an 30% aqueous solution of sodium hydroxide, and the mixture was heated and refluxed for 1.5 hours. After distilling off the methanol, the resulting residue was extracted with chloroform. After drying over anhydrous magnesium sulfate, the solvent was distilled off. The residue was recrystallized from ethyl acetate-n-hexane to give 8-hydroxymethylquinoline (9.21 g).

後処理

  1. temperaturethe mixture was heated
  2. temperaturerefluxed for 1.5 hours
  3. distillationAfter distilling off the methanol
  4. extractionthe resulting residue was extracted with chloroform
  5. dry with materialAfter drying over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off
  7. customThe residue was recrystallized from ethyl acetate-n-hexane

出典と根拠

ORDレコード
ord-954b08e55d2248718904bd63c0437371
出典データセット
uspto-grants-1990_10
特許番号
US04963566

反応ノート

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