Sodium Hydroxide → HCID 14685752、化合物
反応式
O=C1[O:7][CH2:6][C:5]2[CH:8]=[CH:9][CH:10]=[C:11]3[CH:12]([N:15]([CH3:19])[CH2:16][CH:17]=[CH2:18])[CH2:13][CH2:14][N:3]1[C:4]=23.[OH-].[Na+]>CO>[CH3:19][N:15]([CH:12]1[C:11]2[C:4](=[C:5]([CH2:6][OH:7])[CH:8]=[CH:9][CH:10]=2)[NH:3][CH2:14][CH2:13]1)[CH2:16][CH:17]=[CH2:18]参加物
4
実験手順
To a solution of 6,7-dihydro-3-oxo-7-(N-methyl-N-allylamino)-1H,3H,5H-pyrido[3,2,1-ij][3,1]benzoxazine (5.89 g) in methanol (80 ml) was added 15% aqueous solution of sodium hydroxide (20 ml) and the mixture was refluxed for 6 hours. After distilling off methanol and extracting with dichloromethane, the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off to give 4-(N-methyl-N-allylamino)-8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (4.83 g).
後処理
- temperaturethe mixture was refluxed for 6 hours
- distillationAfter distilling off methanol
- extractionextracting with dichloromethane
- dry with materialthe extract was dried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off
出典と根拠
- ORDレコード
- ord-326edb2efc114f51bd093489be4da1d0
- 出典データセット
- uspto-grants-1990_10
- 特許番号
- US04963566
反応ノート
読み込み中…