Sodium Hydroxide → HCID 23707652、化合物

HRID 1088831ノート

反応式

HRID 1088831 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:21][CH2:22][C:23]([O:25]C)=[O:24])[CH:18]=3)[CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+:28]>CO.O1CCCC1>[Na+:28].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH:12]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:21][CH2:22][C:23]([O-:25])=[O:24])[CH:18]=3)[CH2:13]2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14820516HCID 14820516、化合物

生成物 1

HCID 23707652HCID 23707652、化合物収率 77%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

Into a solution of 0.46 g of methyl N-[2-(4-chlorophenyl)sulfonylaminoindan-5-yl]glycinate dissolved in 20 ml of a mixture of methanol-tetrahydrofuran (1:1) is added 1.22 ml of an aqueous 1 N sodium hydroxide solution, and the mixture is stirred at room temperature overnight, and further at 60° C. for 3 hours. After the reaction, the solvent is evaporated, and the residue is recrystallized from an isopropyl alcohol-water mixture to give 0.37 g of N-[2-(4-chlorophenyl)sulfonylaminoindan-5-yl]glycine sodium salt as colorless crystals.

後処理

  1. waitfurther at 60° C. for 3 hours
  2. customAfter the reaction
  3. customthe solvent is evaporated
  4. customthe residue is recrystallized from an isopropyl alcohol-water mixture

出典と根拠

ORDレコード
ord-b8f7cb65f100402c8ea2084137ca95b4
出典データセット
uspto-grants-1990_10
特許番号
US04963587

反応ノート

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