Thionyl Chloride → 2-(Chloromethyl)-3,4-dimethoxypyridine

HRID 1089117ノート

反応式

HRID 1089117 の反応式
[CH3:1][O:2][C:3]1[C:4]([CH2:11]O)=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O=S(Cl)[Cl:15].C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]([CH2:11][Cl:15])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 107258093,4-Dimethoxy-2-pyridinemethanol

生成物 1

HCID 50797222-(Chloromethyl)-3,4-dimethoxypyridine収率 162.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

3,4-Dimethoxy-2-hydroxymethylpyridine (0.34 g, 0.002 mol) was dissolved in CH2Cl2 (8 ml). SOCl2 (0.27 g, 0.00227 mol) in CH2Cl2 (2 ml) was added under stirring at room temperature. After 10 min the mixture was neutralized with NaHCO3 (5 ml). The phases were separated, the CH2Cl2 phase was washed with NaCl-solution, dried over Na2SO4 and evaporated giving the desired product (0.61 g, 88%).

後処理

  1. customThe phases were separated
  2. washthe CH2Cl2 phase was washed with NaCl-solution
  3. dry with materialdried over Na2SO4
  4. customevaporated

出典と根拠

ORDレコード
ord-58a80bb84e824ffcac598bac364ec0bd
出典データセット
uspto-grants-1990_10
特許番号
US04965269

反応ノート

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