Hydrochloric Acid → 4-(Aminomethyl)pyrrolidin-3-ol dihydrochloride

HRID 1089219ノート

反応式

HRID 1089219 の反応式
[OH:1][CH:2]1[CH:6]([CH2:7][NH2:8])[CH2:5][N:4](CC2C=CC=CC=2)[CH2:3]1.[ClH:16]>CO.C(O)C.[Pd]>[ClH:16].[ClH:16].[OH:1][CH:2]1[CH:6]([CH2:7][NH2:8])[CH2:5][NH:4][CH2:3]1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 139598933-Hydroxy-4-aminomethyl-1-phenylmethyl pyrrolidine

生成物 1

HCID 148395874-(Aminomethyl)pyrrolidin-3-ol dihydrochloride収率 70%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

A solution of 2.9 g (10.6 mmol) of 3-hydroxy-4-aminomethyl-1-phenylmethyl pyrrolidine in 60 ml anhydrous methanol and 5.3 ml 5N hydrochloric acid in ethanol was hydrogenized over 1.83 g palladium on carbon for 17 hours. The catalyst was filtered off, the solvent removed to afford 1.39 g (70%) of title compound.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed

出典と根拠

ORDレコード
ord-b559d7a33a894657babbbff36d1cdec3
出典データセット
uspto-grants-1990_10
特許番号
US04965273

反応ノート

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