4-Methyl-5-benzofuranol → HCID 14484951、化合物
反応式
[CH3:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:11].[H][H]>C(O)C.[Pd]>[CH3:1][C:2]1[C:7]2[CH2:8][CH2:9][O:10][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:11]参加物
5
実験手順
A solution of 35 (1.86 g, 12.6 mmol) in absolute ethanol (50 mL) was hydrogenated over 10% palladium on carbon catalyst (0.10 g) at 3 atmospheres pressure. After the required amount of hydrogen had been taken up (overnight) the catalyst was removed by filtration and washed with an additional portion of absolute ethanol (20 mL). The combined filtrate and washings were concentrated to a white crystalline solid (1.88 g). Recrystallization from toluene gave 36.
後処理
- custom(overnight)
- customwas removed by filtration
- washwashed with an additional portion of absolute ethanol (20 mL)
- concentrationThe combined filtrate and washings were concentrated to a white crystalline solid (1.88 g)
- customRecrystallization from toluene
出典と根拠
- ORDレコード
- ord-c0c6cdf6956746e9af7996e528de3115
- 出典データセット
- uspto-grants-1990_10
- 特許番号
- US04966907
反応ノート
読み込み中…