関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Phenylphosphonic dichloride | HCID 69990 | — |
| 反応物 | 10-methoxy 6-methyl 5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline | HCID 11021716 | — |
| 生成物 | HCID 178421631 | HCID 178421631 | 54.2% |
反応手順
1.053 g (0.004 mole) of 10-methoxy 6-methyl 5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline are suspended in 5.6 ml (0.040 mole) of dichlorophenylphosphine oxide and the suspension is heated at 160° C. for 2 hours. The reaction mixture is poured onto ice and the pH is brought to 7 by the addition of 10N sodium hydroxide. After filtration and drying of the precipitate formed, 0.580 g of 10-chloro 6-methyl 5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05079363 |
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| 出典データセット | uspto-grants-1992_01 |
|---|
| ORD ID | ord-08169c61c9704b24a6bef8b60afbebe0 |
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| 出典メモ | uspto-grants-1992_01 |
|---|
