HCID 601959、化合物 → 3-(Trimethylsilyl)aniline

HRID 1090418ノート

反応式

HRID 1090418 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([Si:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-])=O>C1C=CC=CC=1.[Pd]>[CH3:11][Si:10]([CH3:13])([CH3:12])[C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[NH2:1]

参加物

4

反応物 1

HCID 601959HCID 601959、化合物

生成物 1

HCID 124888833-(Trimethylsilyl)aniline収率 99.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 241Benzene溶媒

実験手順

m-Nitrotrimethylsilylbenzene (200 mg) was catalytically hydrogenated over Pd-C in 7.5 ml of benzene at atmospheric pressure for 40 minutes. The catalyst was filtered off and washed with benzene and dry MeOH, successively. The filtrate and washings were mixed and evaporated. The residue was purified by column chromatography on silica gel [eluent: methylene chloride] to give 169 mg of pale brown liquid.

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with benzene and dry MeOH
  3. additionThe filtrate and washings were mixed
  4. customevaporated
  5. customThe residue was purified by column chromatography on silica gel [eluent: methylene chloride]

出典と根拠

ORDレコード
ord-ab4926736b4a4afe870c4d8e79b7ac00
出典データセット
uspto-grants-1992_01
特許番号
US05081271

反応ノート

読み込み中…