Silica → 5-(Benzyloxy)pentanal

HRID 1090459

反応式

HRID 1090459 の反応式
[C:1]1([CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][OH:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Si](=O)=O.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[Si]([O-])([O-])([O-])[O-].[Mg+2].[Mg+2]>C(Cl)Cl.C(OCC)C>[C:1]1([CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

7

反応物 4

HCID 24261SilicaHCID 66225Magnesium orthosilicateHCID 2211945-(Benzyloxy)pentan-1-olHCID 178418287HCID 178418287、化合物

生成物 1

HCID 110632585-(Benzyloxy)pentanal収率 78.7%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

Under a nitrogen atmosphere a mixture of 8.0 grams (0.041 mole) of 7-phenyl-6-oxaheptan-1-ol and 1.4 grams of 95% silicon dioxide in 125 ml of methylene chloride was stirred, and 19.8 grams (0.090 mole) of pyridinium chlorochromate was added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for four hours. After this time the reaction mixture was diluted with diethyl ether and then was passed through a column of magnesium silicate. The eluate was concentrated under reduced pressure yielding 6.2 grams of 7-phenyl-6-oxaheptan-1-al. The reaction was repeated.

後処理

  1. additionUpon completion of addition
  2. stirringthe reaction mixture was stirred at ambient temperature for four hours
  3. concentrationThe eluate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-520dbc8b40a94caab5f42feba8bec5b3
出典データセット
uspto-grants-1992_01
特許番号
US05081287

関連ノート

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