Sodium Hydroxide → 1-Phenyl-1H-pyrazole-5-carboxylic acid

HRID 1090809ノート

反応式

HRID 1090809 の反応式
[C:1]1([N:7]2[C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([N:7]2[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 6424675Ethyl 1-phenyl-1H-pyrazole-5-carboxylate

生成物 1

HCID 2370561-Phenyl-1H-pyrazole-5-carboxylic acid収率 81%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4.4 g of ethyl 1-phenylpyrazole-5-carboxylate from Example 1 were stirred for 6 hours at room temperature with 10 ml of 16.5% strength aqueous NaOH and 10 ml of ethanol; the ethanol was removed by distillation, the aqueous phase was extracted twice with 10 ml of toluene, and the pH was adjusted to 3 using concentrated HCl. The precipitate was filtered off under suction, washed with a little water and dried: 3.1 g of product of boiling point 182°-183° C. were obtained.

後処理

  1. customthe ethanol was removed by distillation
  2. extractionthe aqueous phase was extracted twice with 10 ml of toluene
  3. filtrationThe precipitate was filtered off under suction
  4. washwashed with a little water
  5. customdried

出典と根拠

ORDレコード
ord-f3576e277ae6453ba71ef2be29dddc90
出典データセット
uspto-grants-1992_01
特許番号
US05082949

反応ノート

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