Isobutyraldehyde → HCID 67909148、化合物

反応式

[ClH:1].Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:13][CH2:14][NH:15][CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]2[N:21]=[N:22][C:23]([NH:26][NH2:27])=[CH:24][CH:25]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].[CH:29](=O)[CH:30]([CH3:32])[CH3:31]>>[ClH:1].[ClH:1].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:13][CH2:14][NH:15][CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]2[N:21]=[N:22][C:23]([NH:26][N:27]=[CH:29][CH:30]([CH3:32])[CH3:31])=[CH:24][CH:25]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

参加物

反応物 2

HCID 6561Isobutyraldehyde

HCID 19913985HCID 19913985、化合物

生成物 1

HCID 67909148HCID 67909148、化合物収率 71%

実験手順

In a similar manner to Example 8 reaction of 2 g of (RS)-3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-6-hydrazinopyridazine dihydrochloride with (1.1 ml) of isobutyraldehyde afforded the title compound in 71% yield, m.p. 150°-152° C. (with decomp).

出典と根拠

ORDレコード: ord-114209571fc942aa87e94fe382317978
出典データセット: uspto-grants-1992_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05082939

反応ノート

読み込み中…