Sodium borohydride → (2-Trimethylsilyl-4-furyl)methanol

HRID 1090877ノート

反応式

HRID 1090877 の反応式
[CH3:1][Si:2]([CH3:11])([CH3:10])[C:3]1[O:4][CH:5]=[C:6]([CH:8]=[O:9])[CH:7]=1.[BH4-].[Na+]>CO>[OH:9][CH2:8][C:6]1[CH:7]=[C:3]([Si:2]([CH3:11])([CH3:10])[CH3:1])[O:4][CH:5]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 156632515-(Trimethylsilyl)furan-3-carbaldehyde

生成物 1

HCID 13333558(2-Trimethylsilyl-4-furyl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Trimethylsilyl-4-furaldehyde (1.57 g, 9.35 mmol) was added to a suspension of sodium borohydride (424 mg, 11.2 mmol) in methanol (10 ml) at 0° C. After 45 minutes, most of the methanol was evaporated and the residue taken up in ethyl ether. The ethyl ether extracts were combined, washed (water), dried (magnesium sulfate) and evaporated to dryness to give an oil, which was purified by flash chromotography on silica using 30% ethyl ether/hexane to give the title alcohol as a pale yellow oil.

後処理

  1. custommost of the methanol was evaporated
  2. washwashed (water)
  3. dry with materialdried (magnesium sulfate)
  4. customevaporated to dryness
  5. customto give an oil, which
  6. customwas purified by flash chromotography on silica using 30% ethyl ether/hexane

出典と根拠

ORDレコード
ord-ae4bda673c3849729cb1b87d6b324f55
出典データセット
uspto-grants-1992_01
特許番号
US05082954

反応ノート

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