N-[4-[2-Hydroxy-3-[methyl[(6-nitro-2-quinolinyl)methyl]amino]propoxy]phenyl]methanesulfonamide → N-[4-[3-[[(6-Amino-2-quinolinyl)methyl]methylamino]-2-hydroxypropoxy] phenyl]methanesulfonamide

HRID 1091090ノート

反応式

HRID 1091090 の反応式
[OH:1][CH:2]([CH2:16][N:17]([CH3:32])[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([N+:29]([O-])=O)[CH:25]=2)[N:20]=1)[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][CH:6]=1>C(O)C.O=[Pt]=O>[NH2:29][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][CH:23]=1)[N:20]=[C:19]([CH2:18][N:17]([CH3:32])[CH2:16][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][CH:6]=1)[CH:28]=[CH:27]2

参加物

4

反応物 1

HCID 15675910N-[4-[2-Hydroxy-3-[methyl[(6-nitro-2-quinolinyl)methyl]amino]propoxy]phenyl]methanesulfonamide

生成物 1

HCID 15675911N-[4-[3-[[(6-Amino-2-quinolinyl)methyl]methylamino]-2-hydroxypropoxy] phenyl]methanesulfonamide収率 89%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

N-[4-[2-Hydroxy-3-[methyl[(6-nitro-2-quinolinyl)methyl]amino]propoxy]phenyl]methanesulfonamide (1.20 g, 2.61 mmol) and PtO2 (0.120 g, 10% by wt.) were suspended in ethanol (100 mL) and the flask was charged with H2 (1 atm). After stirring for 6 hours, the mixture was filtered through a pad of solka floc and the filtrate was concentrated in vacuo to afford 1.00 g of product as a pale oil which was used directly in the next step.

後処理

  1. additionthe flask was charged with H2 (1 atm)
  2. filtrationthe mixture was filtered through a pad of solka floc
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-0e1bc9f8d1da410195f9c0d913604234
出典データセット
uspto-grants-1992_01
特許番号
US05084463

反応ノート

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