N-Methyl-6-nitro-N-[(4-nitrophenoxy)propyl]-2-quinoline-methanamine → 6-Amino-N-[(4-aminophenoxy)propyl]-N-methyl-2-quinoline methanamine

HRID 1091097ノート

反応式

HRID 1091097 の反応式
[CH3:1][N:2]([CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-])=O)=[CH:23][CH:22]=1)[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:14]([O-])=O)[CH:10]=2)[N:5]=1>C(O)C.O=[Pt]=O>[NH2:14][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]([CH2:3][N:2]([CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([NH2:27])=[CH:25][CH:26]=1)[CH3:1])[CH:13]=[CH:12]2

参加物

4

反応物 1

HCID 15675923N-Methyl-6-nitro-N-[(4-nitrophenoxy)propyl]-2-quinoline-methanamine

生成物 1

HCID 156759246-Amino-N-[(4-aminophenoxy)propyl]-N-methyl-2-quinoline methanamine収率 98.6%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

N-Methyl-6-nitro-N-[(4-nitrophenoxy)propyl]-2-quinoline methanamine (2.60 g, 6.57 mmol) was dissolved in ethanol (170 mL) containing PtO2 (0.39 g). The mixture was charged with H2 (g) (1 atm), stirred for 4 hours, and filtered through a pad of solka floc. The filtrate was concentrated to afford 2.18 g of product as a yellow oil that was used directly without purification.

後処理

  1. additionThe mixture was charged with H2 (g) (1 atm)
  2. filtrationfiltered through a pad of solka floc
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-0aa05394e292401c83cc1f0d7edb2be6
出典データセット
uspto-grants-1992_01
特許番号
US05084463

反応ノート

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