Acetic Acid → HCID 66591971、化合物

HRID 1091302ノート

反応式

HRID 1091302 の反応式
C([N:8]1[CH2:13][CH:12]([CH3:14])[O:11][CH:10]([CH3:15])[CH2:9]1)C1C=CC=CC=1.[C:16]([OH:19])(=[O:18])[CH3:17]>C(O)C.[OH-].[OH-].[Pd+2]>[C:16]([OH:19])(=[O:18])[CH3:17].[CH3:15][CH:10]1[O:11][CH:12]([CH3:14])[CH2:13][NH:8][CH2:9]1

参加物

5

反応物 2

HCID 176Acetic AcidHCID 122940934-Benzyl-2,6-dimethylmorpholine

生成物 1

HCID 66591971HCID 66591971、化合物収率 92%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

4-Benzyl-2,6-dimethylmorpholine (10.72 mg, 45.76 mmol) was dissolved in acetic acid (10 mL) and ethanol (200 mL), and 10% palladium hydroxide/carbon (5 g) was added thereto. The mixture was stirred for two days at room temperature under a hydrogen stream at normal pressure. The catalyst was separated by filtration, and then the reaction liquor was concentrated under reduced pressure and dried, to obtain the title compound (7.36 g, 92%) as an oily matter. This compound was used in the subsequent reaction without performing further purification.

後処理

  1. customThe catalyst was separated by filtration
  2. concentrationthe reaction liquor was concentrated under reduced pressure
  3. customdried

出典と根拠

ORDレコード
ord-69a9203784cf4e1faba18f42c935af9c
出典データセット
uspto-grants-2012_03
特許番号
US08129366B2

反応ノート

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