Sodium Hydroxide → (2S)-2-(4-bromophenyl)oxirane
反応式
[OH-].[Na+].Br[CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[OH:6]>C(OCC)C>[Br:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[CH2:4][O:6]2)=[CH:8][CH:9]=1参加物
4
実験手順
Aqueous sodium hydroxide (1M, 400 ml) was added to 2-bromo-(1S)-1-(4-bromophenyl)ethanol (77.0 g) in diethyl ether (400 ml) and stirred at room temperature for 5 hours. The organic layer was separated and aqueous layer was extracted with ether. The combined organic layer was washed with brine and dried over anhydrous sodium sulfate. Removal of the solvent yielded (2S)-2-(4-bromophenyl) oxirane (55.0 g) as a pale brown oil.
後処理
- customThe organic layer was separated
- extractionaqueous layer was extracted with ether
- washThe combined organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- customRemoval of the solvent
出典と根拠
- ORDレコード
- ord-339c6f5186ae4c92b386345a07b37205
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08129377B2
反応ノート
読み込み中…