Water → HCID 57599729、化合物

HRID 1091522ノート

反応式

HRID 1091522 の反応式
[NH2:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH2:13][O:14][CH3:15])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=S.O.[CH2:31](N)[CH2:32][NH2:33]>>[NH:5]1[CH2:31][CH2:32][N:33]=[C:4]1[C:3]1[C:2]([NH2:1])=[C:9]([O:10][CH3:11])[C:8]([O:12][CH2:13][O:14][CH3:15])=[CH:7][CH:6]=1

参加物

5

反応物 4

HCID 962WaterHCID 3301EthylenediamineHCID 14817Phosphorus sulfide (P2S5)HCID 57599653HCID 57599653、化合物

生成物 1

HCID 57599729HCID 57599729、化合物収率 51.1%

実験手順

A solution of 2-amino-3-methoxy-4-(methoxymethoxy)benzonitrile 475 mg (2.28 mmol) and phosphorus pentasulfide 25.4 mg (0.11 mmol) in ethylenediamine 2.75 g was stirred at 120° C. for overnight. The reaction mixture was cooled to room temperature and poured into water. The precipitate was collected and washed with water to give the title compound 293 mg as white solid. Yield 51.1%.

後処理

  1. customThe precipitate was collected
  2. washwashed with water

出典と根拠

ORDレコード
ord-d9e349da703a456b8a0bd0657ab107da
出典データセット
uspto-grants-2012_03
特許番号
US08129386B2

反応ノート

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