Trifluoroacetic acid → 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-yl-pyrimidine Trifluoroacetic Acid Salt

HRID 1091942

反応式

HRID 1091942 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([CH2:20][O:21][C:22]3[CH:27]=[C:26]([CH:28]([CH3:30])[CH3:29])[CH:25]=[CH:24][C:23]=3[CH3:31])=[C:18]([CH3:32])[N:17]=[C:16]([Cl:33])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>C(Cl)Cl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[Cl:33][C:16]1[N:17]=[C:18]([CH3:32])[C:19]([CH2:20][O:21][C:22]2[CH:27]=[C:26]([CH:28]([CH3:29])[CH3:30])[CH:25]=[CH:24][C:23]=2[CH3:31])=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:15]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 575313954-[2-Chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 866021422-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-yl-pyrimidine Trifluoroacetic Acid Salt

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (500 mg, 1.05 mmol) in DCM (5 mL) is added trifluoroacetic acid (1 mL) with magnetic stirring. Gas evolution is observed and continues for 20 min. The light yellow colored solution is evaporated at reduced pressure, diluted with DCM (20 mL) and evaporated again. Placed under high vacuum (˜0.2 Torr) for 20 min to obtain the title compound as a colorless oil. LC/MS (Method 2), M+H=432.1, Rt=1.46 min.

後処理

  1. customThe light yellow colored solution is evaporated at reduced pressure
  2. additiondiluted with DCM (20 mL)
  3. customevaporated again
  4. waitPlaced under high vacuum (˜0.2 Torr) for 20 min

出典と根拠

ORDレコード
ord-683d19f0f3c14ce28352cb288a1fb24a
出典データセット
uspto-grants-2012_03
特許番号
US08129395B2

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