1-[4-(3-Phenylpropyl)piperidin-1-yl]octan-3-one → 6-{2-[4-(3-Phenylpropyl)piperidin-1-yl]ethyl}undecan-6-ol

HRID 1091976ノート

反応式

HRID 1091976 の反応式
[CH2:1]([Mg]Br)[CH2:2][CH2:3][CH2:4][CH3:5].[C:8]1([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25](=[O:31])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:19][CH2:18]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1COCC1>[C:8]1([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][C:25]([OH:31])([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:21][CH2:22]2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 115372371-[4-(3-Phenylpropyl)piperidin-1-yl]octan-3-oneHCID 178445865HCID 178445865、化合物

生成物 1

HCID 115169256-{2-[4-(3-Phenylpropyl)piperidin-1-yl]ethyl}undecan-6-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1 equivalent of pentylmagnesium bromide was reacted with 1 equivalent of the compound obtained in Example 2, in anhydrous THF, under nitrogen, at room temperature. The product thus obtained was worked up and purified on a column of silica. The results of the NMR and mass spectrometry analyses were in accordance with the expected structure.

後処理

  1. customThe product thus obtained
  2. custompurified on a column of silica
  3. customThe results of the NMR and mass spectrometry analyses

出典と根拠

ORDレコード
ord-ed41e67c4c8746b18580eaeb8cf44201
出典データセット
uspto-grants-2012_03
特許番号
US08129409B2

反応ノート

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