Hydrochloric Acid → 2-Methylamino-2-phenyl-propionitrile
反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].[C-:10]#[N:11].[Na+].[CH3:13][NH2:14].Cl>CO.O>[CH3:10][NH:11][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)([CH3:2])[C:13]#[N:14]参加物
7
反応条件
- 温度
- 40 °C
実験手順
To a solution of acetophenone (10 g) in 50 mL methanol, a solution of sodium cyanide (12.23 g) and methylamine.HCl (16.71 g) in 50 mL water was added slowly at room temp. The reaction mixture was heated at 40° C. for 2 h and then at room temperature for 18 h and was monitored by TLC. After completion, the reaction mixture was extracted with 3×100 mL dichloromethane. The organic layer was then dried over Na2SO4 and concentrated to afford the desired 2-methylamino-2-phenyl-propionitrile (12.5 g) which was used in the next step without further purification.
後処理
- extractionAfter completion, the reaction mixture was extracted with 3×100 mL dichloromethane
- dry with materialThe organic layer was then dried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-11228abea3e84550b1cc74aa0fc53977
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08129423B2
反応ノート
読み込み中…