HCID 59596828、化合物 → 2-[3-(3-Fluoro-benzyloxy)-phenyl]-ethylamine

HRID 1092389ノート

反応式

HRID 1092389 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=2)[CH:11]=1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[F:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[CH2:17][O:16][C:12]1[CH:11]=[C:10]([CH2:9][CH2:8][NH2:7])[CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 1

HCID 59596828HCID 59596828、化合物

生成物 1

HCID 236253522-[3-(3-Fluoro-benzyloxy)-phenyl]-ethylamine

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 10.36 g (30 mmol) of [2-[3-(3-fluoro-benzyloxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester in 100 ml of dichloromethane and 15 ml of trifluoroacetic acid was stirred at room temperature overnight. The solvent was removed, a 5% K2CO3 solution in water was added and the product was extracted with ethyl acetate to obtain the title compound in quantitative yield as a sticky oil.

後処理

  1. customThe solvent was removed
  2. additiona 5% K2CO3 solution in water was added
  3. extractionthe product was extracted with ethyl acetate

出典と根拠

ORDレコード
ord-5bf7c2af2a004311ab6f11bafe2ae74e
出典データセット
uspto-grants-2012_03
特許番号
US08129427B2

反応ノート

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